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2016年9月22日——学术报告(一)
2016年09月18日     (阅读次数:)

 

 

 

报告题目:mTOR---疼痛治疗的新靶位

 

mTOR,A New Target for Cancer Pain, Neuropathic Nain and Opioid Tolerance  

 

报告时间:922日(周四)上午9:00

 

报告地点:常州大学制药与生命科学学院学术报告厅

 

(常州科教城天润科技大厦A614室)

 

人:陶元祥博士

 

陶元祥博士,美国罗格斯大学新泽西州立医学院麻醉系科研部主任,罗格斯大学新泽西州立医学院疼痛医学研究中心主任,医学博士,博士生导师,罗格斯大学新泽西州立医学院麻醉学系,细胞生物学与分子医学系,生理学,药理学与神经科学学系终身教授。国际华人麻醉学院理事会常务理事。现任美国国家国立卫生院 (NIH) 基金申请特邀评审专家和主审专家。中国国家自然科学基金委国家重点项目,国际合作项目,面上项目和青年项目申请特邀海外评审专家和二审主审专家。围术期和疼痛转化医学杂志主编。

 

他的实验室长期从事神经科学与疼痛学的基础及临床转化研究,对慢性疼痛和阿片类药耐受的发病分子和细胞机制有着深刻探讨。近几年来取得的主要研究结果发表在国际一流杂志(比如Nature Neuroscience, Journal ofClinical Investigation, Journal of Neuroscience)和专业顶级杂志(比如 Pain, Anesthesiology)。2011年获得美国疼痛协会授予的Rita Allen 疼痛研究学者(Pain Scholar)荣誉称号。已经申请4项抗慢性疼痛药美国专利,已完成多项NIH和私人基金支持项目。目前实验室NIH在研项目5R011U01。电子邮件:yt211@njms.rutgers.edu Wechat ID: taowangtalk  

 

报告简介:

 

The development ofopioid-induced analgesic tolerance and hyperalgesia is a clinical challenge formanaging chronic pain including neuropathic pain and cancer pain. Adaptivechanges in protein translation in the nervous system are thought to promoteopioid tolerance and hyperalgesia; however, it remains elusive as to howopioids drive such changes. Here, we report thatmTOR, which governs most protein translation, was activatedin rat spinal dorsal horn neurons after repeated intrathecal morphineinjections. Activation was triggered through µ opioid receptor and mediated byintracellular PI3K/Akt. Spinal mTOR inhibition blocked both induction andmaintenance of morphine tolerance and hyperalgesia, without affecting basalpain perception or locomotor functions. These effects were attributed to theattenuation of morphine-induced increases in translation initiation activity,nascent protein synthesis, and expression of some known keytolerance-associated proteins, including neuronal nitric oxide synthase (nNOS),in dorsal horn. Moreover, elevating spinal mTOR activity by knocking down themTOR negative regulator TSC2reduced morphine analgesia, produced pain hypersensitivity, and increasedspinal nNOS expression. Our findings implicate the µ opioid receptor-triggeredPI3K/Akt/mTOR pathway in promoting morphine-induced spinal protein translationchanges and associated morphine tolerance and hyperalgesia. These data suggestthat mTOR inhibitors could be explored for prevention and/or reduction ofopioid tolerance in chronic pain management.

 

 

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