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2017年06月01日     (阅读次数:)



报告题目(Title)Cyclic nucleotide phosphodiesterase-4(PDE4) subtypes as potential targets for neuropsychiatric drugs.

报告人(Speaker)Dr. JamesM. O'Donnell, Professor and Dean of the School of Pharmacy and Pharmaceutical Sciences at the State University of New York (SUNY) at Buffalo, NY, USA.

时间 (Time)201765上午09:30

地点 (Place):敏行楼316(护理系教室)


报告内容简介 (Brief Abstract):

       Considerablepreclinical and clinical evidence suggests that inhibitors of PDE4 have effectson central nervous system function and behavior consistent with therapeuticutility for treating disorders such as depression and dementia. Despite thispromise, dose-limiting side effects such as nausea and emesis has slowed drugdevelopment. Limiting drug action to specific PDE4 subtypes (i.e., PDE4A, B, C,and D) offers a means to produce therapeutic effects while minimizing sideeffects. However, the highly conserved catalytic site, to which classical PDE4inhibitors bind, has limited the discovery of subtype-selective inhibitors. Recently,it has been shown that allosteric inhibitors, which do not bind to thecatalytic site, can demonstrate subtype selectivity. Our research has showndistinct pharmacological profiles for selective inhibitors of PDE4B and PDE4Din models to assess antidepressant and memory-enhancing efficacy.